Sinisa Mihajlovic has rarely changed his starting lineup this season and could name the same XI for the second match in a row, particularly after victory over Cagliari.
This is in part down to Bologna's hefty injury list, with the likes of Nicola Sansone, Gary Medel and Andrea Poli all currently sidelined.
Kostas Manolas, Tiemoue Bakayoko and Victor Osimhen were all rested against Rijeka but should return to the Napoli side.
Neither Alex Meret nor David Ospina has been able to nail down the number one spot so far this season, so the latter may get the nod on Sunday simply because he sat out the Europa League game.
Bologna possible starting lineup:
Skorupski; Silvestri, Danilo, Tomiyasu, Hickey; Schouten, Svanberg; Orsolini, Soriano, Barrow; Palacio
Napoli possible starting lineup:
Ospina; Lorenzo, Manolas, Koulibaly, Hysaj; Ruiz, Bakayoko; Lozano, Mertens, Insigne; Osimhen